Intradermal Vaccination and Experimental Infection of Ac- Tinobacillus Pleuropneumoniae in Pigs

Level of immunity introduced by single or multiple intradermal administrations of various concentrations of antigen in vaccination dose was studied in the paper. Intradermally administered vaccine against Actinobacillus pleuropneumoniae developed comparable immunity to vaccines administered intramuscularly. In spite of intramuscularly induced immunity, there is little known about immunity developed after intradermal administration of different concentrations of antigen in vaccination dose. Intradermal commercial vaccine, containing lipopolysacharid, outer membrane protein and toxins was used, diluted and/or concentrated. The challenge infection was used three weeks after revaccination and protection developed after administration of different concentrations was evaluated and compared to intramuscular administration. Intradermal route was found as comparable to intramuscular administration in protection of lungs against infection, three-time diluted dose was found unless equally effective as standard i.d. or i.m. dose, comparable to 4 times concentrated and 9 times diluted i.d. vaccine.